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Dejerine–Sottas disease, also known as, Dejerine–Sottas neuropathy, Dejerine–Sottas syndrome, progressive hypertrophic interstitial polyneuropathy of childhood, demyelinating polyneuropathy of childhood, and onion bulb neuropathy (and, hereditary motor and sensory polyneuropathy type III and Charcot–Marie–Tooth disease type 3), is a hereditary neurological disorder characterised by damage to the peripheral nerves, demyelination, and resulting progressive muscle wasting and somatosensory loss. The condition is caused by mutations in a various genes and currently has no known cure.
The disorder is named for Joseph Jules Dejerine and Jules Sottas, French neurologists who first described it.